Searle Pakistan Limited (SPL) was incorporated in Pakistan as a Private Limited Company on October 5, 1965 as a subsidiary of G.D. Searle & Co., U.S.A. In 1966, Searle Pakistan (Private) Limited acquired a small manufacturing facility in S.I.T.E. and production of Aldactone, Lomotil, Diodoquin, Ovulen, Neomycin Sulphate, Probanthine and Hydryllin, etc. started there. Over the years the operation expanded and during 1984 construction of a new factory started. During mid 1986 manufacturing operations of high quality pharmaceutical products commenced at this newly built factory at Plot # F-319, S.I.T.E. Area, Karachi, measuring 5.24 acres.
On 29th April 1993, G.D. Searle & Company as part of its global policy, disinvested its shares in Pakistan. On November 14, 1993, the company was converted into a Public Limited Company
As a further milestone, during 1996 Ministry of Health, Islamabad, also allowed the manufacturing of Antibiotic products in a dedicated area constructed within SPL present manufacturing facility where production of some excellent antibiotic drugs is being carried out.
During 1996 SPL also joined a limited group of Pharmaceutical Companies, which are allowed to manufacture semi-basic active raw material for pharmaceutical preparations in their manufacturing facilities.