Searle Pakistan Limited (SPL) was incorporated in Pakistan as a Private Limited Company on October 5, 1965 as a subsidiary of G.D. Searle & Co., U.S.A. In 1966, Searle Pakistan (Private) Limited acquired a small manufacturing facility in S.I.T.E. and production of Aldactone, Lomotil, Diodoquin, Ovulen, Neomycin Sulphate, Probanthine and Hydryllin, etc. started there. Over the years the operation expanded and during 1984 construction of a new factory started. During mid 1986 manufacturing operations of high quality pharmaceutical products commenced at this newly built factory at Plot # F-319, S.I.T.E. Area, Karachi, measuring 5.24 acres.